Pubertal blockers for transgender and gender-diverse youth – Mayo Clinic News Network

Featured conditions
Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.
Transgender and gender-diverse children might choose to temporarily suppress puberty through the use of prescription medications called pubertal blockers. But deciding to get this treatment is a big step.
The medications mostly commonly used to suppress puberty are known as gonadotropin-releasing hormone (GnRH) analogues. Here’s what you need to know about the benefits, side effects and long-term effects.
Puberty’s physical changes can cause intense distress for many gender-nonconforming adolescents. When taken regularly, GnRH analogues suppress the body’s release of sex hormones, including testosterone and estrogen, during puberty.
Sex hormones affect:
In those identified as male at birth, GnRH analogues decrease the growth of facial and body hair, prevent voice deepening, and limit the growth of genitalia.
In those identified as female at birth, treatment limits or stops breast development and stops menstruation.
Gender dysphoria is the feeling of discomfort or distress that might accompany a difference between experienced or expressed gender and sex assigned at birth. Gender dysphoria that starts in childhood and worsens with the start of puberty rarely goes away.
For children who have gender dysphoria, suppressing puberty might:
However, puberty suppression alone might not ease gender dysphoria.
To begin using pubertal blockers, a child must:
Particularly when a child hasn’t reached the age of medical consent, parents or other caretakers or guardians must consent to the treatment and support the adolescent through the treatment process.
Use of GnRH analogues pauses puberty, providing time to determine if a child’s gender identity is long lasting. It also gives children and their families time to think about or plan for the psychological, medical, developmental, social and legal issues ahead.
If an adolescent child decides to stop taking GnRH analogues, puberty will resume and the normal progression of the physical and emotional changes of puberty will continue.
For most children, puberty begins around ages 10 to 11, though puberty sometimes starts earlier. The effect of pubertal blockers depends on when a child begins to take the medication. GnRH analogue treatment can begin at the start of puberty to delay secondary sex characteristics. In slightly later stages of puberty, the treatment could be used to stop menstruation or erections or to prevent further development of undesired secondary sex characteristics.
While most children take the medication for a few years, every child is different. After suppressing puberty for a few years, your child might decide to stop puberty blocking therapy or pursue other hormone treatments.
GnRH analogue treatments for children are prescribed, administered and monitored by a pediatric endocrinologist. The medication is typically given as injections, either monthly or every three months, or through an implant placed under the skin of the upper arm. The implant typically needs to be replaced every 12 months.
While taking pubertal blockers, your child will have regular blood tests to monitor the medication’s effectiveness. Your child will also be monitored for any side effects.
It’s important for your child to stay on schedule with all related medical appointments. Contact your child’s doctor if any changes cause you or your child concern.
Possible side effects of GnRH analogue treatment include:
Use of GnRH analogues might also have long-term effects on:
Children may have their height checked every three months. Bone density is also checked periodically. If bone growth or density is a concern, your child’s health care provider might prescribe a different medication, stop treatment with GnRH analogues or recommend the best time to start cross-hormone therapy.
If children with male genitalia begin using GnRH analogues early in puberty, they might not develop enough penile and scrotal skin for certain gender affirming genital surgical procedures, such as penile inversion vaginoplasty. Alternative techniques, however, are available.
In addition, delaying puberty beyond one’s peers can be stressful. Your child might experience lower self-esteem.
Assessment and counseling by a behavioral health provider can help you and your child as you move through the decision-making process and provide support during therapy. Engaging your child’s schoolteachers and officials also might help ease your child’s social adjustment during this process.
After a period of adjusting to pubertal blockers, adolescents might work with their care team to add cross-hormone treatment. This is done to develop masculine or feminine secondary sex characteristics, helping the mind and body look and act like the gender with which your child identifies. Keep in mind that some of these changes aren’t reversible or will require surgery to reverse the effects.
GnRH analogues aren’t the only medications that can delay puberty. If you’re interested in alternative treatments, talk to your child’s doctor.
There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form.
Receive trusted health information and answers to your questions about sexual orientation, gender identity, transition, self-expression, and LGBTQ+ health topics. Click here for an email preview.
ErrorEmail field is required
ErrorInclude a valid email address
To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.
You will receive the first newsletter in your inbox shortly. This will include exclusive health content about the LGBTQ+ community from Mayo Clinic.
If you don’t receive our email within 5 minutes, check your SPAM folder, then contact us at
Please, try again in a couple of minutes
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.
Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press.
Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
A single copy of these materials may be reprinted for noncommercial personal use only. “Mayo,” “Mayo Clinic,” “,” “Mayo Clinic Healthy Living,” and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.


Leave a Comment